The hotel opened on June 1, 1887 as a luxury health resort. It was built by the North Alabama Improvement Company with funding from Michael and James O'Shaughnessy. The hotel closed in 1900 and was demolished in 1944.
This pamphlet announces the opening of the Hotel Monte Sano on June 1, 1887 and lists the manager as "Mr. S.E. Bates." The first section of the pamphlet includes a brief history of Huntsville and a description of the city's amenities. The author extolls the health advantages of Huntsville as "most healthfully situated at the base of Monte Sano" and describes the city's lack of recent disease outbreaks. The second section of the pamphlet details the Hotel Monte Sano's furnishings and amenities. The author emphasizes the "healthful" environs of the mountain and the hotel and includes letters from Huntsville's "eminent physicians" as testimonials. The pamphlet includes illustrations of scenes from Huntsville and Monte Sano.
